FOERFARANDE FOER ISOLERING AV KOAGULATIONSFAKTORER OCH DAERTILL LAEMPLIGT ADSORBERINGSAEMNE

This invention relates to a process and to adsorbent material for isolating coagulation factors, including FVIII and vWF, from for example blood plasma and plasma products by means of liquid chromatography. The adsorbent material comprises a polymeric carrier to which amino groups are linked as liga...

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Bibliographische Detailangaben
Hauptverfasser:	VAN AKEN, WILLEM GERARD, BANTJES, ADRIAAN, TE BOOY, MARCELINUS PETRUS WILHELMUS MARIA, KOENIG, BOUDEWIJN WYNAND, BEUGELING, TOM, RIETHORST, WAANDER
Format:	Patent
Sprache:	fin
Schlagworte:	BEER BIOCHEMISTRY CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING THEIR RELEVANT APPARATUS TRANSPORTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	This invention relates to a process and to adsorbent material for isolating coagulation factors, including FVIII and vWF, from for example blood plasma and plasma products by means of liquid chromatography. The adsorbent material comprises a polymeric carrier to which amino groups are linked as ligands through spacers. The spacers have a chain length of at least 6 atoms and contain at least one hydrophilic link within the chain. The spacers preferably have the formula -(CH2)m-CO-NH-(CH2)n- wherein m and n each represent an integer of 1-6 and m+n is at least 4. The spacers are preferably linked to the carrier through -CO-NH- groups. The ligand density in the adsorbent material is preferably higher than 30 umoles/ml of swollen matrix.