TUMOERNEKROSISFAKTOR

Human tumor necrosis factor (TNF) has been prepared using recombinant methods. A human promyelocytic leukemia cell line has been induced using an improved induction procedure, and the TNF purified to homogeneity. Methods, vectors, and cells useful in obtaining human TNF in practical amounts are disc...

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Hauptverfasser: MARK, DAVID FUI, CREASEY, ABLA ABU-ZAYYAD, LADNER, MARTHA BALLIE, LIN, LEO SHUN LEE, WANG, ALICE MING, VAN ARSDELL, JANELLE NOBLE
Format: Patent
Sprache:fin
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Zusammenfassung:Human tumor necrosis factor (TNF) has been prepared using recombinant methods. A human promyelocytic leukemia cell line has been induced using an improved induction procedure, and the TNF purified to homogeneity. Methods, vectors, and cells useful in obtaining human TNF in practical amounts are disclosed. Muteins having N-terminal deletions, which muteins have superior biological activity, are also disclosed.