FOERFARANDE FOER FRAMSTAELLNING AV 6-PURINYL-N-/2-KLORETYL/KARBAMAT OCH -TIOKARBAMAT
The invention relates to 6-purinyl N-(2-chloroethyl) carbamate and thiocarbamate of the general formula I …… in which X stands for an oxygen or sulphur atom, and to a process for their preparation by reacting a purine derivative of the general formula II …… (hypoxanthine or 6-mercaptopurine, respect...
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| creator | BEITOVA, MARTA KREPELKA, JIRI CERNY, ANTONIN MIKO, MILAN POKORNA, STANISLAVA MELKA, MILAN GRIMOVA, JAROSLAVA REICHLOVA, RUZENA KEJHOVA, IRENA |
| description | The invention relates to 6-purinyl N-(2-chloroethyl) carbamate and thiocarbamate of the general formula I …… in which X stands for an oxygen or sulphur atom, and to a process for their preparation by reacting a purine derivative of the general formula II …… (hypoxanthine or 6-mercaptopurine, respectively) with 2-chloroethylisocyanate. The compounds of formula I show a remarkable antineoplastic effect in vitro and in vivo, and consequently provide a potential treatment for malignant neoplastic diseases in mammals. |
| format | Patent |
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The compounds of formula I show a remarkable antineoplastic effect in vitro and in vivo, and consequently provide a potential treatment for malignant neoplastic diseases in mammals.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | FOERFARANDE FOER FRAMSTAELLNING AV 6-PURINYL-N-/2-KLORETYL/KARBAMAT OCH -TIOKARBAMAT |
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