FOERFARANDE FOER FRAMSTAELLNING AV 6-PURINYL-N-/2-KLORETYL/KARBAMAT OCH -TIOKARBAMAT

The invention relates to 6-purinyl N-(2-chloroethyl) carbamate and thiocarbamate of the general formula I …… in which X stands for an oxygen or sulphur atom, and to a process for their preparation by reacting a purine derivative of the general formula II …… (hypoxanthine or 6-mercaptopurine, respect...

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Bibliographische Detailangaben
Hauptverfasser:	BEITOVA, MARTA, KREPELKA, JIRI, CERNY, ANTONIN, MIKO, MILAN, POKORNA, STANISLAVA, MELKA, MILAN, GRIMOVA, JAROSLAVA, REICHLOVA, RUZENA, KEJHOVA, IRENA
Format:	Patent
Sprache:	fin
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to 6-purinyl N-(2-chloroethyl) carbamate and thiocarbamate of the general formula I …… in which X stands for an oxygen or sulphur atom, and to a process for their preparation by reacting a purine derivative of the general formula II …… (hypoxanthine or 6-mercaptopurine, respectively) with 2-chloroethylisocyanate. The compounds of formula I show a remarkable antineoplastic effect in vitro and in vivo, and consequently provide a potential treatment for malignant neoplastic diseases in mammals.