FOERFARANDE FOER DIASTEREOSELEKTIV REDUKTION AV 3-AMINO-1-BENSOXEPIN-5(2H)-ONER

FOERFARANDE FOER DIASTEREOSELEKTIV REDUKTION AV 3-AMINO-1-BENSOXEPIN-5(2H)-ONER

A process for producing cis-2,3,4,5-tetrahydro-3-amino-1-benzoxepin-5-ols in which 3-amino-1-benzoxepin-5(2H)-ones are diastereoselectively reduced in a single stage by catalytic hydrogenation in the presence of a platinum oxide catalyst and an equivalent amount of an acid in a polar protic solvent,...

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Bibliographische Detailangaben
Hauptverfasser: OHLENDORF, HEINRICH WILHELM, MAETZEL, UWE
Format: Patent
Sprache:fin
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:A process for producing cis-2,3,4,5-tetrahydro-3-amino-1-benzoxepin-5-ols in which 3-amino-1-benzoxepin-5(2H)-ones are diastereoselectively reduced in a single stage by catalytic hydrogenation in the presence of a platinum oxide catalyst and an equivalent amount of an acid in a polar protic solvent, or by reaction with a borane/amine complex in an aprotic solvent, optionally in the presence of an added lower aliphatic carboxylic acid.