NYA ARYLAETTIKSYRADERIVAT

A compound having a potentially inhibitory effect on 15-hydroxy-prostaglandin dehydrognase (PGDH) and having the formulain whichR1 and R2 are hydrogen or lower alkyl;R3 is hydrogen, lower alkyl or substituted or unsubstituted phenyl;R4, R5 and Re are hydrogen, halogen, lower alkyl, lower alkoxy, cyano, carboxy or nitro; at least one of the groups R4 to R6 being hydrogen;R7 to R11 are hydrogen, halogen, cyano, lower alkyl, trifluoromethyl, lower alkoxy, hydroxy, lower acyl, lower alkoxycarbonyl, N,N,-diloweralkyl-aminocarbonyl or N,N-loweralkylene-aminocarbonyl; and R8 to R10 may in addition be carboxy; at least two of R7 to R11 always being hydrogen; and -A- is -CO-, -CH2-CO-, -CH=CH-, -CH=CH-CO- or corresponding groups in which a hydrogen atom is replaced by a lower alkyl group.The invention comprises also lactones of those compounds in which R1 is hydrogen, and salts of those compounds which contain at least one carboxy group.