KARBOXYLATPLATINA(II)BLANDKOMPLEX SAMT FOERFARANDE FOER DERAS FRAMSTAELLNING

PCT No. PCT/SU84/00001 Sec. 371 Date Sep. 4, 1985 Sec. 102(e) Date Sep. 4, 1985 PCT Filed Jan. 23, 1984 PCT Pub. No. WO85/03296 PCT Pub. Date Aug. 1, 1985.Novel platinum(II) carboxylatocomplexes of the following general formula: wherein R is tetrahydrofurfuryl or cyclo-CnR''2n-1, R'&#...

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Hauptverfasser:	KONOVALOVA, ALEXANDRA LEONIDOVNA, CHELTSOV-BEBUTOV, PETR ALEXANDROVICH, SCHELOKOV, ROBERT NIKOLAEVICH, IVANOV, VIKTOR BORISOVICH, KRAVCHENKO, ALEXANDR NIKOLAEVICH, PRESNOV, MIKHAIL ALEXEEVICH
Format:	Patent
Sprache:	fin
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	PCT No. PCT/SU84/00001 Sec. 371 Date Sep. 4, 1985 Sec. 102(e) Date Sep. 4, 1985 PCT Filed Jan. 23, 1984 PCT Pub. No. WO85/03296 PCT Pub. Date Aug. 1, 1985.Novel platinum(II) carboxylatocomplexes of the following general formula: wherein R is tetrahydrofurfuryl or cyclo-CnR''2n-1, R'' is H, an alkyl, hydroxyl, n=3-6; R' is -CH2-, -CH2-CH2-, -CH(OH)-, -CH(OH)-CH2-, -CH(OH)-CH(OH)-. These compounds possess a clearly pronounced antitumor activity and are readily soluble in water. A process for preparing these compounds comprises reacting K [PtCl3NH3] with KI, followed by treatment of the reaction mixture with tetrahydrofurfurylamine or an alicyclic amine and treatment of the resulting mixture of complexes with a silver salt of the formula: Ag2(OOC-R'-COO), wherein R' is as identified above.