TRICYKLISKA FOERENINGAR, FOERFARANDEN FOER FRAMSTAELLNING AV DESSA, SAODANA FOERENINGAR INNEHAOLLANDE KOMPOSITIONER OCH DERAS ANVAENDNING INOM MEDICINEN

Compounds of formula (I) wherein n is 0, 1 or 2; one of R and R is hydrogen and the other is selected from carbamoyl, N-C1-4 alkylcarbamoyl, N,N-di-C1-4 alkylcarbamoyl, carbamimidoyl, N -C1-4 alkylcarbamimidoyl, N -C1-4 alkylcarbamimidoyl, N -C1-4 alkyl-N -C1-4 alkylcarbamimidoyl, N ,N di-C1-4 alkyl...

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Hauptverfasser: HARFENIST, MORTON, HEUSER, DARRYL JAMES, JOYNER, CHARLES THOMAS
Format: Patent
Sprache:fin
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Zusammenfassung:Compounds of formula (I) wherein n is 0, 1 or 2; one of R and R is hydrogen and the other is selected from carbamoyl, N-C1-4 alkylcarbamoyl, N,N-di-C1-4 alkylcarbamoyl, carbamimidoyl, N -C1-4 alkylcarbamimidoyl, N -C1-4 alkylcarbamimidoyl, N -C1-4 alkyl-N -C1-4 alkylcarbamimidoyl, N ,N di-C1-4 alkylcarbamimidoyl, N ,N -di-C1-4alkyl-N -C1-4 alkylcarbamimidoyl, tetrazol-5-yl (optionally substituted by one or more C1-4 alkyl groups) and linidazolin-2-yl (optionally substituted by one or more C1-4 alkyl groups); and R is selected from hydrogen, saturated and unsaturated aliphatic hydrocarbon moieties containing from 1 to 4 carbon atoms, groups OR (where R is selected from hydrogen and saturated and unsaturated aliphatic hydrocarbon moieties containing from 1 to 4 carbon atoms), halo, groups of formula -NR R (where R and R are independently selected from hydrogen, C1-4 alkyl and hydroxy C1-4 alkyl, provided that the total number of carbon atoms in R and R does not exceed 4), amino C1-4 alkylamino and morpholino, provided that when R is carbamoyl and R and R are both hydrogen, then n is 0 or 1; and physiologically acceptable salts thereof, and their pro-drugs and metabolites are inhibitors of monoamine oxidase-A and are useful in the prophylaxis and treatment of mental disorders such as depression.