FOERFARANDE FOER FRAMSTAELLNING AV TERAPEUTISKT ANVAENDBAR KRISTALLFORM ÇAÇAV 1-BENZHYDYL-4 -ALLYLPIPERAZINDIHYDROKLORID

A novel anhydrous crystalline form of 1-benzhydryl-4-allylpiperazine dihydrochloride which possesses absorption bands in its IR-spectra (tablets with nujol mulls) at 646 and 665 cm , a ratio A646/A661 = 0.6, a specific triplet at 915, 926 and 952 cm , a ratio A926/A952 = 0.8, absence of a band at 33...

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Hauptverfasser: EVSTATIEVA, ANKA VELTSHEVA, ZIKOLOVA, TATYANA STOYANOVA, MITZEV, GEORGI KIRILOV, NIKOLOV, RUMEN KOSTOV, VITKOVA, SNEJANA GEORGIEVA, KARAKOLEV, PAVEL VASSILEV, NINOV, KIRIL ASSENOV
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Sprache:fin
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Zusammenfassung:A novel anhydrous crystalline form of 1-benzhydryl-4-allylpiperazine dihydrochloride which possesses absorption bands in its IR-spectra (tablets with nujol mulls) at 646 and 665 cm , a ratio A646/A661 = 0.6, a specific triplet at 915, 926 and 952 cm , a ratio A926/A952 = 0.8, absence of a band at 3380 cm and a strongest X-ray diffraction band at 27.4 2 theta , corresponding to 37.8 nm and good water solubility properties rendering it suitable for use in preparation for sterile injectable solutions is prepared by acidifying solutions of 1-benzhydryl-4-allylpiperazine in aqueous alcoholic media.