NYA 1-BENZYL-3,4-DIHYDRO-ISOKINOLINDERIVAT

The invention relates to the new 6,7-diethoxy-1-(4-ethoxy-3-hydroxy-benzyl)-3,4-dihydro-isoquinoline of the Formula I and physiologically acceptable salts thereof. The compound of the Formula I and salts thereof can be prepared by hydrolysing a compound of the general Formula VI (wherein R is a grou...

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Hauptverfasser:	SZEKERES, LASZLO, PAPP, GYULA, SZANTAY, CSABA, GYOERGI, PETER, KALAUS, GYOERGY, UDVARY, EVA, DAVID, AGOSTON
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Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	SZEKERES, LASZLO PAPP, GYULA SZANTAY, CSABA GYOERGI, PETER KALAUS, GYOERGY UDVARY, EVA DAVID, AGOSTON
description	The invention relates to the new 6,7-diethoxy-1-(4-ethoxy-3-hydroxy-benzyl)-3,4-dihydro-isoquinoline of the Formula I and physiologically acceptable salts thereof. The compound of the Formula I and salts thereof can be prepared by hydrolysing a compound of the general Formula VI (wherein R is a group removable by hydrogenolysis) preferably a benzyl group and R is an alkyl group having 1-6 carbon atoms), reacting the compound of the general Formula V thus obtained (wherein R is as stated above) with an amine of the general Formula IV or a salt thereof in the presence of a catalyst, subjecting the amide of the general Formula III thus obtained (wherein R is as stated above) to ring-closure and subjecting the compound of the General Formula II (wherein R is as stated above) or a salt thereof thus obtained to hydrogenolysis and if desired converting the compound of the Formula I thus obtained into a physiologically acceptable salt thereof or setting free the same from its salt.
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The compound of the Formula I and salts thereof can be prepared by hydrolysing a compound of the general Formula VI (wherein R is a group removable by hydrogenolysis) preferably a benzyl group and R is an alkyl group having 1-6 carbon atoms), reacting the compound of the general Formula V thus obtained (wherein R is as stated above) with an amine of the general Formula IV or a salt thereof in the presence of a catalyst, subjecting the amide of the general Formula III thus obtained (wherein R is as stated above) to ring-closure and subjecting the compound of the General Formula II (wherein R is as stated above) or a salt thereof thus obtained to hydrogenolysis and if desired converting the compound of the Formula I thus obtained into a physiologically acceptable salt thereof or setting free the same from its salt.</description><edition>3</edition><language>fin</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1982</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19821217&DB=EPODOC&CC=FI&NR=822133L$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19821217&DB=EPODOC&CC=FI&NR=822133L$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SZEKERES, LASZLO</creatorcontrib><creatorcontrib>PAPP, GYULA</creatorcontrib><creatorcontrib>SZANTAY, CSABA</creatorcontrib><creatorcontrib>GYOERGI, PETER</creatorcontrib><creatorcontrib>KALAUS, GYOERGY</creatorcontrib><creatorcontrib>UDVARY, EVA</creatorcontrib><creatorcontrib>DAVID, AGOSTON</creatorcontrib><title>NYA 1-BENZYL-3,4-DIHYDRO-ISOKINOLINDERIVAT</title><description>The invention relates to the new 6,7-diethoxy-1-(4-ethoxy-3-hydroxy-benzyl)-3,4-dihydro-isoquinoline of the Formula I and physiologically acceptable salts thereof. 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subjects	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	NYA 1-BENZYL-3,4-DIHYDRO-ISOKINOLINDERIVAT
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