FOERFARANDE FOER FRAMSTAELLNING AV CEFUROXIM-1-ACETOXIETYLESTER

FOERFARANDE FOER FRAMSTAELLNING AV CEFUROXIM-1-ACETOXIETYLESTER

A process for obtaining highly pure crystalline cefuroxime axetil comprises crystallising cefuroxime axetil from a solution thereof in an organic or aqueous solvent or a mixture thereof and then drying and isolating the product. Preferred solvents are alkyl acetates in admixture with ethers or aliph...

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Bibliographische Detailangaben
Hauptverfasser: OUGHTON,JOHN FRANCIS, TURNBULL,JOHN PETER, CRISP,HAROLD ALFRED, WRIGHT,MICHAEL
Format: Patent
Sprache:fin ; swe
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:A process for obtaining highly pure crystalline cefuroxime axetil comprises crystallising cefuroxime axetil from a solution thereof in an organic or aqueous solvent or a mixture thereof and then drying and isolating the product. Preferred solvents are alkyl acetates in admixture with ethers or aliphatic or aromatic hydrocarbons. The higher the yield from crystallisation, the closer to a 1:1 stoichiometric ratio of R:S isomers the product will contain, this being most desirable for an antibiotic product which is to be administered orally.