FOERFARANDE FOER FRAMSTAELLNING AV FARMAKOLOGISKT AKTIVA PROSTAGLANDINDERIVAT

1529852 8-Azaprostaglandins LABAZ 11 March 1976 [21 March 1975] 12034/75 Headings C2C and C2P The invention comprises 8-azaprostaglandins of the Formula I wherein R is H, methyl or ethyl and their preparation by standard methods. The following intermediates are also prepared: silver methyl suberate,...

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Bibliographische Detailangaben
Hauptverfasser:	EYMARD PIERRE LUC, SIMIAND JACQUES, PIGEROL CHARLES, JEAN ALAIN
Format:	Patent
Sprache:	fin
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	1529852 8-Azaprostaglandins LABAZ 11 March 1976 [21 March 1975] 12034/75 Headings C2C and C2P The invention comprises 8-azaprostaglandins of the Formula I wherein R is H, methyl or ethyl and their preparation by standard methods. The following intermediates are also prepared: silver methyl suberate, 1-chloro-2-heptanone, ethyl DL-pyroglutamate DL-6-hydroxymethyl - 2 - pyrrolidinone, and its 2 - tetrahydropyranyl ether; methyl and ethyl 2-hydroxymethyl - 5 - oxo - 1 - pyrrolidineheptanoate and its 2 - tetrahydropyranyl ether; ethyl and methyl 2 - formyl - 5 - oxo - 1 - pyrrolidineheptanoate; methyl and ethyl 2 - (3 - oxo - -trans- 1 - octenyl) - 5 - oxo - 1 - pyrrolidineheptanoate; diethyl (5 - acetoxypentyl)malonate; 7 - bromoheptanoic acid and its methyl and ethyl esters; and ethyl 3-oxooctanoate. (2 - Oxoheptylidene)triphenylphosphorane is prepared by reacting potassium carbonate with (2 - oxoheptyl)triphenylphosphonium chloride obtained by reacting triphenyl phosphine with 1-chloro-2-heptanone. Pharmaceutical compositions contain the 8- azaprostaglandins of Formula I above in association with non-toxic carriers or excipients therefor. The compounds possess similar pharmacological properties to those of PGE.