FOERFARANDE FOER FRAMSTAELLNING AV 6,7-DIMETOXI-4-AMINO-2-(4-(2-FUROYL)-1-PIPERAZINYL)KINAZOLIN MED BLODTRYCKSSAENKANDE VEKAN

FOERFARANDE FOER FRAMSTAELLNING AV 6,7-DIMETOXI-4-AMINO-2-(4-(2-FUROYL)-1-PIPERAZINYL)KINAZOLIN MED BLODTRYCKSSAENKANDE VEKAN

A novel process is provided for the preparation of 6,7-dimethoxy-4-amino-24-(2-furoyl)-1-piperazinyl!quinazoline. It includes as a final step, cyclizing methyl-N-(3,4-dimethoxy-6-cyanophenyl)-4-(2-furoyl)-1-piperazinyl! thioformamidate by heating, together with ammonia, in a polar solvent, in the pr...

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Bibliographische Detailangaben
Hauptverfasser: HONKANEN ERKKI JUHANI, PIPPURI AINO KYLLIKKI
Format: Patent
Sprache:fin
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:A novel process is provided for the preparation of 6,7-dimethoxy-4-amino-24-(2-furoyl)-1-piperazinyl!quinazoline. It includes as a final step, cyclizing methyl-N-(3,4-dimethoxy-6-cyanophenyl)-4-(2-furoyl)-1-piperazinyl! thioformamidate by heating, together with ammonia, in a polar solvent, in the presence of an alkali metal amide. The methyl-N-(3,4-dimethoxy-6-cyanophenyl)-4-(2-furoyl)-1-piperazinyl!thio formamidate is preferably formed by reacting 3,4-dimethoxy-6-4-(2-furoyl)-1-piperazinyl-thiocarbamido!benzonitrile with methyl chloride. By this process the quinazoline ring in prazosine is produced within the molecule, rather than in a reaction between two different molecules.