FOERFARANDE FOER FRAMSTAELLNING AV FARMAKOLOGISKT VAERDEFULLA 1-(3,4-DIMETOXIFENETYLAMINO)-3-FENOXY-2-PROPANOLFOERENINGAR

FOERFARANDE FOER FRAMSTAELLNING AV FARMAKOLOGISKT VAERDEFULLA 1-(3,4-DIMETOXIFENETYLAMINO)-3-FENOXY-2-PROPANOLFOERENINGAR

1-(3,4-Dimethoxyphenethylamino)-3-(substituted phenoxy)-2-propanols; and acid-addition salts. The substituent in the 3-(substituted phenoxy) group can be lower alkoxy, chloro, cyano, hydroxymethyl, acetyl, m-lower alkyl, or o-allyl. The compounds are pharmacological agents, especially beta-adrenergi...

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Bibliographische Detailangaben
Hauptverfasser: MEYER ROBERT FREDERICK, HOLMES ANN
Format: Patent
Sprache:fin
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:1-(3,4-Dimethoxyphenethylamino)-3-(substituted phenoxy)-2-propanols; and acid-addition salts. The substituent in the 3-(substituted phenoxy) group can be lower alkoxy, chloro, cyano, hydroxymethyl, acetyl, m-lower alkyl, or o-allyl. The compounds are pharmacological agents, especially beta-adrenergic blocking agents with cardio-selective activity. They can be produced by reacting a 1-halo-3-(substituted phenoxy)-2-propanol with 3,4-dimethoxyphenethylamine; or by reacting a 1,2-epoxy-3-(substituted phenoxy)propane with 3,4-dimethoxyphenethylamine. Starting materials for use in those processes are obtained by reacting a phenol or a sodium phenolate with epichlorohydrin under varying conditions.