METHOD FOR SYNTHESISING DIESTERS OF 2-BROMO GLUTARIC ACID

The present invention relates to a process for preparing the 2-bromoglutaric acid diester of formula (I) below:comprising the formation of the 2-hydroxyglutaric acid diester of formula (II)by reaction of butyrolactone acid of formula (BA)with the alcohol of formula ROH, in the presence of an acid su...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	PARATIAN, Jean-Michel, CERF, Martine
Format:	Patent
Sprache:	eng ; fin
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The present invention relates to a process for preparing the 2-bromoglutaric acid diester of formula (I) below:comprising the formation of the 2-hydroxyglutaric acid diester of formula (II)by reaction of butyrolactone acid of formula (BA)with the alcohol of formula ROH, in the presence of an acid such as sulfuric acid; and bromination of the 2-hydroxyglutaric acid diester of formula (II), by sparging with gaseous hydrobromic acid.The present invention also relates to a 2-bromoglutaric acid diester of formula (I), having a degree of purity determined by HPLC analysis of greater than or equal to 90%.