A PROCESS FOR THE PREPARATION OF PYRVINIUM PAMOATE AND CRYSTALLINE FORMS THEREOF

A PROCESS FOR THE PREPARATION OF PYRVINIUM PAMOATE AND CRYSTALLINE FORMS THEREOF

The present invention relates to a process for the preparation of pyrvinium pamoate, which comprises reacting pyrvinium methyl sulphate salt of formula (II) with disodium pamoate of formula (III), in the presence of a base; to processes for the preparation of crystalline Form A and crystalline Form...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: DEL RÍO PERICACHO, José Luis, MARTÍ VIA, Josep, CÁNOVAS PAREDES, Antonio De Padua
Format: Patent
Sprache:eng ; fin
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention relates to a process for the preparation of pyrvinium pamoate, which comprises reacting pyrvinium methyl sulphate salt of formula (II) with disodium pamoate of formula (III), in the presence of a base; to processes for the preparation of crystalline Form A and crystalline Form III of pyrvinium pamoate; as well as a process for the purification of crystalline Form III. It also relates to crystalline Forms A and III of pyrvinium pamoate and to pharmaceutical compositions containing them.