Menetelmä optisesti rikastetun levobupivakaiinin ja siihen läheisesti liittyvien piperidiinikarboksanilidiyhdisteiden rasemisoimiseksi

Menetelmä optisesti rikastetun levobupivakaiinin ja siihen läheisesti liittyvien piperidiinikarboksanilidiyhdisteiden rasemisoimiseksi

An optically-enriched piperidine-2-carboxanilide compound, in which the piperidine is optionally N-alkylated, is racemised by heating the compound in an aqueous medium, provided that the medium includes an organic cosolvent if the compound is N-alkylated. This process is particularly valuable, in co...

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Bibliographische Detailangaben
Hauptverfasser: WOODS,MARTIN, LANGSTON,MARIANNE, DYER,ULRICH CONRAD
Format: Patent
Sprache:fin ; swe
Schlagworte:
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:An optically-enriched piperidine-2-carboxanilide compound, in which the piperidine is optionally N-alkylated, is racemised by heating the compound in an aqueous medium, provided that the medium includes an organic cosolvent if the compound is N-alkylated. This process is particularly valuable, in conjuction with a resolution process, for the manufacture of levobupivacaine.