Pyridopyrimidiinit, jotka pystyvät inhiboimaan epidermisen kasvutekijäreseptoriperheen tyrosiinikinaaseja

Pyridopyrimidiinit, jotka pystyvät inhiboimaan epidermisen kasvutekijäreseptoriperheen tyrosiinikinaaseja

Described are heterocyclic pyrimidine derivatives and a method of inhibiting epidermal growth factor by treating, with an effective inhibiting amount, a mammal, in need thereof, a compound of the formula:where:at least two of A-E are nitrogen, with the remaining atom(s) carbon;X=NH or NR7, such that...

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Bibliographische Detailangaben
Hauptverfasser: KRAKER,ALAN, MEYER,ROBERT FREDERICK, THOMPSON,ANDREW MARK, BRIDGES,ALEXANDER JAMES, FRY,DAVID, REWCASTLE,GORDON WILLIAM, DENNY,WILLIAM ALEXANDER
Format: Patent
Sprache:fin ; swe
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Described are heterocyclic pyrimidine derivatives and a method of inhibiting epidermal growth factor by treating, with an effective inhibiting amount, a mammal, in need thereof, a compound of the formula:where:at least two of A-E are nitrogen, with the remaining atom(s) carbon;X=NH or NR7, such that R7=lower alkyl (1-4 carbon atoms), OH, NH2, lower alkoxy (1-4 carbon atoms) or lower monoalkylamino (1-4 carbon atoms);n=0, 1, 2.The remaining substituents are described in detail in the specification.