Indolijohdannaiset 5-HT1-tyyppisinä agonisteina

PCT No. PCT/EP95/03884 Sec. 371 Date Apr. 3, 1997 Sec. 102(e) Date Apr. 3, 1997 PCT Filed Sep. 29, 1995 PCT Pub. No. WO96/11195 PCT Pub. Date Apr. 18, 1996Compounds of formula (I), pharmaceutically acceptable salts thereof, and pharmaceutically acceptable solvates (including hydrates) of either enti...

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1. Verfasser:	BROWN,ALAN DANIEL
Format:	Patent
Sprache:	fin ; swe
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	PCT No. PCT/EP95/03884 Sec. 371 Date Apr. 3, 1997 Sec. 102(e) Date Apr. 3, 1997 PCT Filed Sep. 29, 1995 PCT Pub. No. WO96/11195 PCT Pub. Date Apr. 18, 1996Compounds of formula (I), pharmaceutically acceptable salts thereof, and pharmaceutically acceptable solvates (including hydrates) of either entity, wherein R1 is (a) R2 is R3R4C(OH)A; V is C=O or CH2; W is O or NR5; R3 and R4 are each independently selected from H and C1-C4 alkyl; or, together with the carbon atom to which they are attached, form a 4- or 5-membered carbocyclic ring; R5 is H, benzyl, C1-C5 alkanoyl or SO2(C1-C4)alkyl; A is C2-C3 alkylene; m is 0 or 1; and n is 0 or 1; with the provisos that when n is 1 and V is C=O then W is NH, and when n is 1 and V is CH2 then W is O; are selective 5-HT1-like agonists useful in the treatment of, inter alia, migraine, cluster headache, chronic paroxysmal hemicrania and headache associated with vascular disorders. (I) (a)