Menetelmä 2-substituoitujen adenosiinien valmistamiseksi, joilla on A-2-reseptoriaffiniteetti

Adenosine analogues which act selectively at adenosine receptors and which act in general as adenosine agonists are disclosed. From (in vitro) studies it is known that specific physiological effects can be distinguished as a result of this selectivity and that adenosine receptor activity (in vitro)...

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Bibliographische Detailangaben
Hauptverfasser: PEET,NORTON PAUL, LENTZ,NELSEN LOWEL, BORCHERDING,DAVID ROGER, WEINTRAUB,PHILIP MARVIN
Format: Patent
Sprache:fin ; swe
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Zusammenfassung:Adenosine analogues which act selectively at adenosine receptors and which act in general as adenosine agonists are disclosed. From (in vitro) studies it is known that specific physiological effects can be distinguished as a result of this selectivity and that adenosine receptor activity (in vitro) correlates with adenosine receptor activity (in vivo). Pharmaceutical preparations of the subject compounds can be prepared on the basis of the selective binding activity of the compounds disclosed herein which will enhance certain physiological effects while minimizing others, such as decreasing blood pressure without decreasing heart rate.