Menetelmä terapeuttisesti käyttökelpoisten yhdisteiden valmistamiseksi

A compound of the formula in which R is hydrogen, halo, C1-4 alkyl, C1-4 alkoxy, nitrile, optionally protected carboxy, optionally protected tetrazolyl, trihalomethyl, hydroxy-C1-4 alkyl, aldehydo,- CH2Z, -CH=CH-Z or -CH2CH2Z where Z is optionally protected carboxy or optionally protected tetrazolyl; R is halo, nitrile, an optionally protected acid group or -CONR R where R and R are each hydrogen or C1-4 alkyl, R and R are each hydrogen, C1-4 alkyl, optionally substituted phenyl, or C1-4 alkyl substituted by -CONR R or an optionally protected acid group; R is where W is -CH=CH-, -CH=N-, -N=CH-, -O- or -S-, R is hydrogen, halo, C1-4 alkyl, C1-4 alkoxy or trihalomethyl, and R is hydrogen, C1-4 alkyl, C2-6 alkenyl, C3-6 cycloalkyl or C1-4 alkyl-C3-6 cycloalkyl; R is hydrogen or C1-4 alkyl; X is -O-(CH2)nCR CR -, -CR R -, -CR R .(CH2)n.CR R - or -CR =CR - where R , R , R and R are each hydrogen or C1-4 alkyl, and n is 0, 1 or 2; and Y is -O-CR R -, -CR =CR - or -CR R .CR R - where R , R , R and R are each hydrogen or C1-4 alkyl; or a salt thereof. The compounds in unprotected form are active as leukotriene antagonists.