Antagonists of the human microRNAs miR-100, miR-20, miR-222, miR-181, and miR-92 and uses thereof (Machine-translation by Google Translate, not legally binding)

Antagonists of the human microRNAs miR-100, miR-20, miR-222, miR-181, and miR-92 and uses thereof. The invention provides inhibitors of the human microRNAs miR-100, miR-20a, miR-222, miR-181c, or miR-92a that are repressors of the MBNL1 and/or MBNL2 genes, and the use of said inhibitors as a medicin...

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Bibliographische Detailangaben
Hauptverfasser:	Cerro Herreros, Estefanía, Moreno Cervera, Nerea, Overby, Sarah Joann, Artero Allepuz, Rubén Darío, González Martínez, Irene, Llamusí Troisi, Beatriz
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Antagonists of the human microRNAs miR-100, miR-20, miR-222, miR-181, and miR-92 and uses thereof. The invention provides inhibitors of the human microRNAs miR-100, miR-20a, miR-222, miR-181c, or miR-92a that are repressors of the MBNL1 and/or MBNL2 genes, and the use of said inhibitors as a medicine, especially against myotonic dystrophy type 1. (Machine-translation by Google Translate, not legally binding) Antagonistas de los microRNA humanos miR-100, miR-20, miR-222, miR-181, y miR-92 y usos de los mismos. La invención proporciona inhibidores de los microRNA humanos miR-100, miR-20a, miR-222, miR-181c, o miR-92a que son represores de los genes MBNL1 y/o MBNL2, y el uso de dichos inhibidores como medicamento, especialmente frente a distrofia miotónica tipo 1.