MODELO ANIMAL DEFICIENTE EN FACTOR V

The present invention relates to a coagulation factor V-deficient non-human animal model that includes an amino acid replacement in the FV protein that reproduces the human mutation Thr1898Met. In particular, the present invention relates to a mouse animal model, with the mutation located in Thr1857Met of the murine FV protein. The invention includes heterozygous and homozygous mutants for this mutation, producing viable litters and subjects with mild clinical signs of the disease which do not cause the animal to suffer. The present invention further relates, on the one hand, to a method for producing non-human coagulation factor V-deficient animals using gene editing and assisted reproduction techniques using zygote microinjection and, on the other hand, to the use of the animal model in the study of drugs for the treatment of coagulation factor V deficiency.