Proteína no fucosilada y métodos de la misma

The present disclosure relates to developing cell lines where specific biological pathways are modified, particularly by modifications in the enzymes of the cell. The present disclosure develops protein expression systems wherein specific modification of glycan chain of the protein is achieved, whic...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	M, Pavithra, M, Sathyabalan, PRASAD, Bhargav, K, Veeresha, PATHAK, Prabhat Kumar, MAITY, Sunit, SRINIVASAN, Sankaranarayanan, BHATTACHARJEE, Sanghamitra, SHENOY, Bharath R, M., Yogendra Manjunath B, MALIWALAVE, Amol, D, Pravin Kumar, GHOSH, Maloy, HALAN, Vivek, UNNIKRISHNAN, Divya, HAZARIKA, Jahnabi, N, Bairavabalakumar, KURUP, Anisha, THANIGAIVEL, Aswini, PENDSE, Rajeshwari, NAIR, Karthika, RODRIGUES, Kavitha Iyer, HORA, Anuradha, CHATTERJEE, Sohang
Format:	Patent
Sprache:	spa
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present disclosure relates to developing cell lines where specific biological pathways are modified, particularly by modifications in the enzymes of the cell. The present disclosure develops protein expression systems wherein specific modification of glycan chain of the protein is achieved, which produces non-fucosylated proteins, including non-fucosylated antibodies. The non-fucosylated proteins are used in developing therapeutic monoclonal antibodies and biomarkers, and in diagnosis and prognosis of various diseases. The present disclosure employs the Transcription Activator like Effector Nuclease (TALEN) technology for inactivating fucosylation in a cell.