Derivados de benzoxazinona para el tratamiento de enfermedades cutáneas

Un compuesto según la Fórmula I **(Ver fórmula)** en donde R es -S-CH3 o -Cl, o una sal farmacéuticamente aceptable del mismo. The present invention relates to methods and compositions for inhibiting the activity of skin proteases, especially human kallikrein 7 (KLK7), human kallikrein 5 (KLK5), and...

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Bibliographische Detailangaben
Hauptverfasser:	LEONARDSSON, Göran, WÅGBERG, Fredrik
Format:	Patent
Sprache:	spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Un compuesto según la Fórmula I (Ver fórmula) en donde R es -S-CH3 o -Cl, o una sal farmacéuticamente aceptable del mismo. The present invention relates to methods and compositions for inhibiting the activity of skin proteases, especially human kallikrein 7 (KLK7), human kallikrein 5 (KLK5), and human kallikrein 14 (KLK14). More specifically, the invention relates to the use of substituted 3,1-benzoxazin-4-ones being selective inhibitors of human skin kallikreins for the treatment of skin diseases, more specifically for the treatment of inflammatory skins diseases, especially Netherton syndrome.