Composición farmacéutica para tratar enfermedades asociadas con la resistencia a la insulina y la disfunción de células beta

2-Metil-4,5-di-(metilsulfonil)-benzoil-guanidina, y/o una sal y/o solvato fisiologicamente aceptable del mismo, para su uso en el tratamiento profilactico o terapeutico de la diabetes mellitus de tipo II o los sintomas que surgen de la diabetes mellitus de tipo II. The invention relates to a pharmaceutical composition comprising as active ingredient an effective amount of 2-Methyl-4,5-di-(methylsulfonyl)-benzoyl-guanidine, or derivatives thereof, for the prophylaxis and therapy of Type II diabetes mellitus, the Metabolic syndrome, diabetic nephropathy and/or neuropathy. Another object of the invention concerns the use of 2-Methyl-4,5-di-(methylsulfonyl)-benzoyl-guanidine, or derivatives thereof, for the enhancement of insulin sensitivity and the preservation or increase of ß-cell compensation.