Formas farmacéuticas de apixaban

Una forma farmacéutica que proporciona liberación controlada de apixaban, comprendiendo la forma farmacéutica una forma de solubilidad mejorada de apixaban que es una dispersión sólida amorfa que comprende dicho apixaban y acetatosuccinato de hidroxipropilmetilcelulosa (HPMCAS). The present invention provides a process for producing a solid amorphous dispersion of apixaban comprising dissolving apixaban and one or more polymers in a solvent, which dissolves both apixaban and the one or more polymers and removing the solvent by spray drying; a solid amorphous dispersion prepared according to the process; as well as a dosage form comprising the solid amorphous dispersion.