METODO PARA EL ESTUDIO DE MUTACIONES EN EMBRIONES EN PROCESOS DE REPRODUCCION IN VITRO

The invention relates to a method for the study of embryo mutations in in vitro reproduction processes with the particular feature that it combines the detection techniques of Aneuploidy (PGD-A) and the study of monogenic diseases in embryos (PGD-M), and wherein the method comprises: a SNP selection...

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Bibliographische Detailangaben
Hauptverfasser:	CASTEJON FERNANDEZ, NATALIA, ALCARAZ MAS, LUIS A
Format:	Patent
Sprache:	spa
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to a method for the study of embryo mutations in in vitro reproduction processes with the particular feature that it combines the detection techniques of Aneuploidy (PGD-A) and the study of monogenic diseases in embryos (PGD-M), and wherein the method comprises: a SNP selection process, wherein the values of some n candidate SNPs (t1... tk) of each subject x, in a chromosomal region of interest and specifically extracted for a study population, are taken as input; a SNP selection process, wherein all the SNP combinations are evauated to obtain a minimum set t of tagSNPs from the matrix M obtained in the first SNP selection process; and a process involving in-silico validation of the tagSNP panel obtained in the second process.