Moduladores P2X7
Una composición farmacéutica que comprende: (a) una cantidad terapéuticamente eficaz de al menos un compuesto seleccionado del grupo que consiste de: (R*)-(2-cloro-3-(trifluorometil)fenil)(1-(5-fluoropirimidin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin- 5(4H)-il)metanona; 5-{[2-fluor...
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| creator | RECH, Jason MANI, Neelakandha ANDRES GIL, Jose Ignacio ALCAZAR VACA, Manuel Jesus SAVALL, Brad WALL, Jessica DENG, Xiaohu CHROVIAN, Christa GELIN, Christine SWANSON, Devin LIANG, Jimmy DVORAK, Curt ALLISON, Brett LETAVIC, Michael SOYODE-JOHNSON, Akinola DE ANGELIS, Meri STENNE, Brice COATE, Heather |
| description | Una composición farmacéutica que comprende: (a) una cantidad terapéuticamente eficaz de al menos un compuesto seleccionado del grupo que consiste de: (R*)-(2-cloro-3-(trifluorometil)fenil)(1-(5-fluoropirimidin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin- 5(4H)-il)metanona; 5-{[2-fluoro-3-(trifluorometil)fenil]carbonil}-1-pirazin-2-il-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridina; (S*)-(3-fluoro-2-(trifluorometil)piridin-4-il)(1-(5-fluoropirimidin-2-il)-6-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5- c]piridin-5(4H)-il)metanona; (R*)-(2-cloro-3-(trifluorometil)fenil)(4-metil-1-(1H-pirazol-5-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)- il)metanona; (6S)-1-(5-fluoropirimidin-2-il)-5-{[2-fluoro-3-(trifluorometil)fenil]carbonil}-6-metil-4,5,6,7-tetrahidro- 1H[1,2,3]triazolo[4,5-c]piridina; y (6R*)-5-[(2,3-dicloro-4-fluorofenil)carbonil]-1-(5-fluoropirimidin-2-il)-6-metil-4,5,6,7-tetrahidro-1H- [1,2,3]triazolo[4,5-c]piridina; y (b) al menos un excipiente farmacéuticamente aceptable, en donde la composición está formulada para administración oral.
The present invention is directed to compounds of Formulas (I, Ia, IIa and IIb):The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, Ia, IIa and IIb). Methods of making and using the compounds of Formulas (I, Ia, IIa and IIb) are also within the scope of the invention. |
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| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_ES2704024TT3</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>ES2704024TT3</sourcerecordid><originalsourceid>FETCH-epo_espacenet_ES2704024TT33</originalsourceid><addsrcrecordid>eNrjZBDwzU8pzUlMyS9KLVYIMIow52FgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8a7BRuYGJgZGJiEhxsbEqAEAf-gfDw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Moduladores P2X7</title><source>esp@cenet</source><creator>RECH, Jason ; MANI, Neelakandha ; ANDRES GIL, Jose Ignacio ; ALCAZAR VACA, Manuel Jesus ; SAVALL, Brad ; WALL, Jessica ; DENG, Xiaohu ; CHROVIAN, Christa ; GELIN, Christine ; SWANSON, Devin ; LIANG, Jimmy ; DVORAK, Curt ; ALLISON, Brett ; LETAVIC, Michael ; SOYODE-JOHNSON, Akinola ; DE ANGELIS, Meri ; STENNE, Brice ; COATE, Heather</creator><creatorcontrib>RECH, Jason ; MANI, Neelakandha ; ANDRES GIL, Jose Ignacio ; ALCAZAR VACA, Manuel Jesus ; SAVALL, Brad ; WALL, Jessica ; DENG, Xiaohu ; CHROVIAN, Christa ; GELIN, Christine ; SWANSON, Devin ; LIANG, Jimmy ; DVORAK, Curt ; ALLISON, Brett ; LETAVIC, Michael ; SOYODE-JOHNSON, Akinola ; DE ANGELIS, Meri ; STENNE, Brice ; COATE, Heather</creatorcontrib><description>Una composición farmacéutica que comprende: (a) una cantidad terapéuticamente eficaz de al menos un compuesto seleccionado del grupo que consiste de: (R*)-(2-cloro-3-(trifluorometil)fenil)(1-(5-fluoropirimidin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin- 5(4H)-il)metanona; 5-{[2-fluoro-3-(trifluorometil)fenil]carbonil}-1-pirazin-2-il-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridina; (S*)-(3-fluoro-2-(trifluorometil)piridin-4-il)(1-(5-fluoropirimidin-2-il)-6-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5- c]piridin-5(4H)-il)metanona; (R*)-(2-cloro-3-(trifluorometil)fenil)(4-metil-1-(1H-pirazol-5-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)- il)metanona; (6S)-1-(5-fluoropirimidin-2-il)-5-{[2-fluoro-3-(trifluorometil)fenil]carbonil}-6-metil-4,5,6,7-tetrahidro- 1H[1,2,3]triazolo[4,5-c]piridina; y (6R*)-5-[(2,3-dicloro-4-fluorofenil)carbonil]-1-(5-fluoropirimidin-2-il)-6-metil-4,5,6,7-tetrahidro-1H- [1,2,3]triazolo[4,5-c]piridina; y (b) al menos un excipiente farmacéuticamente aceptable, en donde la composición está formulada para administración oral.
The present invention is directed to compounds of Formulas (I, Ia, IIa and IIb):The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, Ia, IIa and IIb). Methods of making and using the compounds of Formulas (I, Ia, IIa and IIb) are also within the scope of the invention.</description><language>spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190313&DB=EPODOC&CC=ES&NR=2704024T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190313&DB=EPODOC&CC=ES&NR=2704024T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RECH, Jason</creatorcontrib><creatorcontrib>MANI, Neelakandha</creatorcontrib><creatorcontrib>ANDRES GIL, Jose Ignacio</creatorcontrib><creatorcontrib>ALCAZAR VACA, Manuel Jesus</creatorcontrib><creatorcontrib>SAVALL, Brad</creatorcontrib><creatorcontrib>WALL, Jessica</creatorcontrib><creatorcontrib>DENG, Xiaohu</creatorcontrib><creatorcontrib>CHROVIAN, Christa</creatorcontrib><creatorcontrib>GELIN, Christine</creatorcontrib><creatorcontrib>SWANSON, Devin</creatorcontrib><creatorcontrib>LIANG, Jimmy</creatorcontrib><creatorcontrib>DVORAK, Curt</creatorcontrib><creatorcontrib>ALLISON, Brett</creatorcontrib><creatorcontrib>LETAVIC, Michael</creatorcontrib><creatorcontrib>SOYODE-JOHNSON, Akinola</creatorcontrib><creatorcontrib>DE ANGELIS, Meri</creatorcontrib><creatorcontrib>STENNE, Brice</creatorcontrib><creatorcontrib>COATE, Heather</creatorcontrib><title>Moduladores P2X7</title><description>Una composición farmacéutica que comprende: (a) una cantidad terapéuticamente eficaz de al menos un compuesto seleccionado del grupo que consiste de: (R*)-(2-cloro-3-(trifluorometil)fenil)(1-(5-fluoropirimidin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin- 5(4H)-il)metanona; 5-{[2-fluoro-3-(trifluorometil)fenil]carbonil}-1-pirazin-2-il-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridina; (S*)-(3-fluoro-2-(trifluorometil)piridin-4-il)(1-(5-fluoropirimidin-2-il)-6-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5- c]piridin-5(4H)-il)metanona; (R*)-(2-cloro-3-(trifluorometil)fenil)(4-metil-1-(1H-pirazol-5-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)- il)metanona; (6S)-1-(5-fluoropirimidin-2-il)-5-{[2-fluoro-3-(trifluorometil)fenil]carbonil}-6-metil-4,5,6,7-tetrahidro- 1H[1,2,3]triazolo[4,5-c]piridina; y (6R*)-5-[(2,3-dicloro-4-fluorofenil)carbonil]-1-(5-fluoropirimidin-2-il)-6-metil-4,5,6,7-tetrahidro-1H- [1,2,3]triazolo[4,5-c]piridina; y (b) al menos un excipiente farmacéuticamente aceptable, en donde la composición está formulada para administración oral.
The present invention is directed to compounds of Formulas (I, Ia, IIa and IIb):The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, Ia, IIa and IIb). Methods of making and using the compounds of Formulas (I, Ia, IIa and IIb) are also within the scope of the invention.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBDwzU8pzUlMyS9KLVYIMIow52FgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8a7BRuYGJgZGJiEhxsbEqAEAf-gfDw</recordid><startdate>20190313</startdate><enddate>20190313</enddate><creator>RECH, Jason</creator><creator>MANI, Neelakandha</creator><creator>ANDRES GIL, Jose Ignacio</creator><creator>ALCAZAR VACA, Manuel Jesus</creator><creator>SAVALL, Brad</creator><creator>WALL, Jessica</creator><creator>DENG, Xiaohu</creator><creator>CHROVIAN, Christa</creator><creator>GELIN, Christine</creator><creator>SWANSON, Devin</creator><creator>LIANG, Jimmy</creator><creator>DVORAK, Curt</creator><creator>ALLISON, Brett</creator><creator>LETAVIC, Michael</creator><creator>SOYODE-JOHNSON, Akinola</creator><creator>DE ANGELIS, Meri</creator><creator>STENNE, Brice</creator><creator>COATE, Heather</creator><scope>EVB</scope></search><sort><creationdate>20190313</creationdate><title>Moduladores P2X7</title><author>RECH, Jason ; MANI, Neelakandha ; ANDRES GIL, Jose Ignacio ; ALCAZAR VACA, Manuel Jesus ; SAVALL, Brad ; WALL, Jessica ; DENG, Xiaohu ; CHROVIAN, Christa ; GELIN, Christine ; SWANSON, Devin ; LIANG, Jimmy ; DVORAK, Curt ; ALLISON, Brett ; LETAVIC, Michael ; SOYODE-JOHNSON, Akinola ; DE ANGELIS, Meri ; STENNE, Brice ; COATE, Heather</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ES2704024TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2019</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>RECH, Jason</creatorcontrib><creatorcontrib>MANI, Neelakandha</creatorcontrib><creatorcontrib>ANDRES GIL, Jose Ignacio</creatorcontrib><creatorcontrib>ALCAZAR VACA, Manuel Jesus</creatorcontrib><creatorcontrib>SAVALL, Brad</creatorcontrib><creatorcontrib>WALL, Jessica</creatorcontrib><creatorcontrib>DENG, Xiaohu</creatorcontrib><creatorcontrib>CHROVIAN, Christa</creatorcontrib><creatorcontrib>GELIN, Christine</creatorcontrib><creatorcontrib>SWANSON, Devin</creatorcontrib><creatorcontrib>LIANG, Jimmy</creatorcontrib><creatorcontrib>DVORAK, Curt</creatorcontrib><creatorcontrib>ALLISON, Brett</creatorcontrib><creatorcontrib>LETAVIC, Michael</creatorcontrib><creatorcontrib>SOYODE-JOHNSON, Akinola</creatorcontrib><creatorcontrib>DE ANGELIS, Meri</creatorcontrib><creatorcontrib>STENNE, Brice</creatorcontrib><creatorcontrib>COATE, Heather</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>RECH, Jason</au><au>MANI, Neelakandha</au><au>ANDRES GIL, Jose Ignacio</au><au>ALCAZAR VACA, Manuel Jesus</au><au>SAVALL, Brad</au><au>WALL, Jessica</au><au>DENG, Xiaohu</au><au>CHROVIAN, Christa</au><au>GELIN, Christine</au><au>SWANSON, Devin</au><au>LIANG, Jimmy</au><au>DVORAK, Curt</au><au>ALLISON, Brett</au><au>LETAVIC, Michael</au><au>SOYODE-JOHNSON, Akinola</au><au>DE ANGELIS, Meri</au><au>STENNE, Brice</au><au>COATE, Heather</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Moduladores P2X7</title><date>2019-03-13</date><risdate>2019</risdate><abstract>Una composición farmacéutica que comprende: (a) una cantidad terapéuticamente eficaz de al menos un compuesto seleccionado del grupo que consiste de: (R*)-(2-cloro-3-(trifluorometil)fenil)(1-(5-fluoropirimidin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin- 5(4H)-il)metanona; 5-{[2-fluoro-3-(trifluorometil)fenil]carbonil}-1-pirazin-2-il-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridina; (S*)-(3-fluoro-2-(trifluorometil)piridin-4-il)(1-(5-fluoropirimidin-2-il)-6-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5- c]piridin-5(4H)-il)metanona; (R*)-(2-cloro-3-(trifluorometil)fenil)(4-metil-1-(1H-pirazol-5-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)- il)metanona; (6S)-1-(5-fluoropirimidin-2-il)-5-{[2-fluoro-3-(trifluorometil)fenil]carbonil}-6-metil-4,5,6,7-tetrahidro- 1H[1,2,3]triazolo[4,5-c]piridina; y (6R*)-5-[(2,3-dicloro-4-fluorofenil)carbonil]-1-(5-fluoropirimidin-2-il)-6-metil-4,5,6,7-tetrahidro-1H- [1,2,3]triazolo[4,5-c]piridina; y (b) al menos un excipiente farmacéuticamente aceptable, en donde la composición está formulada para administración oral.
The present invention is directed to compounds of Formulas (I, Ia, IIa and IIb):The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, Ia, IIa and IIb). Methods of making and using the compounds of Formulas (I, Ia, IIa and IIb) are also within the scope of the invention.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Moduladores P2X7 |
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