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Una composición farmacéutica que comprende: (a) una cantidad terapéuticamente eficaz de al menos un compuesto seleccionado del grupo que consiste de: (R*)-(2-cloro-3-(trifluorometil)fenil)(1-(5-fluoropirimidin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin- 5(4H)-il)metanona; 5-{[2-fluor...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	RECH, Jason, MANI, Neelakandha, ANDRES GIL, Jose Ignacio, ALCAZAR VACA, Manuel Jesus, SAVALL, Brad, WALL, Jessica, DENG, Xiaohu, CHROVIAN, Christa, GELIN, Christine, SWANSON, Devin, LIANG, Jimmy, DVORAK, Curt, ALLISON, Brett, LETAVIC, Michael, SOYODE-JOHNSON, Akinola, DE ANGELIS, Meri, STENNE, Brice, COATE, Heather
Format:	Patent
Sprache:	spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Una composición farmacéutica que comprende: (a) una cantidad terapéuticamente eficaz de al menos un compuesto seleccionado del grupo que consiste de: (R)-(2-cloro-3-(trifluorometil)fenil)(1-(5-fluoropirimidin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin- 5(4H)-il)metanona; 5-{[2-fluoro-3-(trifluorometil)fenil]carbonil}-1-pirazin-2-il-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridina; (S)-(3-fluoro-2-(trifluorometil)piridin-4-il)(1-(5-fluoropirimidin-2-il)-6-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5- c]piridin-5(4H)-il)metanona; (R)-(2-cloro-3-(trifluorometil)fenil)(4-metil-1-(1H-pirazol-5-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)- il)metanona; (6S)-1-(5-fluoropirimidin-2-il)-5-{[2-fluoro-3-(trifluorometil)fenil]carbonil}-6-metil-4,5,6,7-tetrahidro- 1H[1,2,3]triazolo[4,5-c]piridina; y (6R)-5-[(2,3-dicloro-4-fluorofenil)carbonil]-1-(5-fluoropirimidin-2-il)-6-metil-4,5,6,7-tetrahidro-1H- [1,2,3]triazolo[4,5-c]piridina; y (b) al menos un excipiente farmacéuticamente aceptable, en donde la composición está formulada para administración oral. The present invention is directed to compounds of Formulas (I, Ia, IIa and IIb):The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, Ia, IIa and IIb). Methods of making and using the compounds of Formulas (I, Ia, IIa and IIb) are also within the scope of the invention.