FUNCTIONALIZED PARTICLES PROTEIN LIGANTS, METHOD OF OBTAINING AND CARTRIDGES OF DIALYSIS CONTAINING SUCH PARTICLES (Machine-translation by Google Translate, not legally binding)

The present invention describes copolymer particles of styrene and methyl methacrylate functionalized on its surface with polyethylene glycol methacrylate. This material allows the immobilization on its surface of proteins through covalent binding. The invention describes the process for obtaining t...

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Bibliographische Detailangaben
Hauptverfasser:	Redondo Calvo, Francisco Javier, Garrido Martín, María del Prado, Padilla Valverde, David, De Lucas Martínez, Antonio, Rodríguez Romero, Juan Francisco, Borreguero Simón, Ana María, Carmona Franco, Manuel Salvador
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY COMPOSITIONS BASED THEREON DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS PHYSICS TESTING THEIR PREPARATION OR CHEMICAL WORKING-UP
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Beschreibung
Zusammenfassung:	The present invention describes copolymer particles of styrene and methyl methacrylate functionalized on its surface with polyethylene glycol methacrylate. This material allows the immobilization on its surface of proteins through covalent binding. The invention describes the process for obtaining the particles and their use in the elimination of toxic compounds present in the blood refractory to dialysis treatments, such as excess bilirubin. The invention also writes dialysis cartridges containing the functionalized particles bound to proteins such as albumin, compatible with the current dialysis systems. (Machine-translation by Google Translate, not legally binding) La presente invención describe partículas de copolímero de estireno y metacrilato de metilo funcionalizadas en su superficie con metacrilato de polietilenglicol. Este material permite la inmovilización en su superficie de proteínas mediante enlace covalente. La invención describe el procedimiento de obtención de las partículas y su uso en la eliminación de compuestos tóxicos presentes en la sangre refractarios a los tratamientos de diálisis, tales como el exceso de bilirrubina. La invención también escribe cartuchos de diálisis que contienen las partículas funcionalizadas unidas a proteínas como la albúmina, compatibles con los actuales sistemas de diálisis.