Gel de colágeno reticulado por radiación, método de preparación del mismo

Un método para preparar un gel de colágeno reticulado por radiación, comprendiendo el método irradiar colágeno líquido con radiación para preparar un colágeno reticulado; en el que la radiación es rayos gamma, en el que la dosis (tasa de dosis x tiempo) de la radiación es de 0,1-40 kGy/h, en el que el método comprende mezclar un 3 % (p/v) de colágeno con uno de un 3 % (p/v) de polímero sintético Pluronic F-127® (poloxámero 407), un 1 % (p/v) de PEO (poli(óxido de etileno) (MW >= 100.000) o un 3 % (p/v) de hidroxiapatita, y reticular la mezcla por irradiación con rayos gamma. The present invention relates to radiation cross-linked collagen gel, and a preparation method and usage method thereof. To this end, the present invention comprises a cross-linked collagen material made by irradiating liquid collagen with radioactive rays, wherein the concentration of said collagen is specifically 0.1-10% (W/V), and the radiation dose (dose rate X time) is 0.1 - 40 kGy on the basis of 1 kGy/hr. The present invention configured as above can prepare a formulated collagen gel using a physical cross-linking method instead of a chemical cross-linking method, specifically carries out the formulation by mixing biocompatible materials, and provides a method capable of using a cross-linked collagen hydrogel in wound dressings, graft materials, cell cultures and the like. Therefore, the present invention provides an industrially convenient and safe preparation method, thereby instilling a good image to a customer by greatly improving the quality and confidence in the products.