Device and microfluid system for the study of cellular crops (Machine-translation by Google Translate, not legally binding)
Device and microfluidic system for the study of cell cultures. The present invention relates to a novel device and a microfluidic system for the cultivation of cellular samples, based on: one or more culture wells (2) that form cell housing volumes for the three-dimensional culture thereof; one or m...
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Sprache: | eng ; spa |
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Zusammenfassung: | Device and microfluidic system for the study of cell cultures. The present invention relates to a novel device and a microfluidic system for the cultivation of cellular samples, based on: one or more culture wells (2) that form cell housing volumes for the three-dimensional culture thereof; one or more capillary channels (1) for the circulation of cells and/or fluid media, said channels (1) being connected to the wells (2) as a perfusion medium thereof; and an inlet port (3) and an outlet port (3 ') for the sowing of cells and/or for the circulation of fluid in said channel (1), said ports (3, 3') connected to the ends of each capillary channel (1). The novel configuration of the ports (3, 3 ') and their corresponding channels (1) makes it possible to improve the known microfluidic perfusion means, avoiding the use of complex elements for injecting the fluid media, such as, for example, syringe pumps. Likewise, the invention makes it possible to carry out, simultaneously, two-dimensional and three-dimensional culture studies. (Machine-translation by Google Translate, not legally binding)
Dispositivo y sistema microfluídico para el estudio de cultivos celulares. La presente invención se refiere a un novedoso dispositivo y a un sistema microfluídico para el cultivo de muestras celulares, basado en: uno o más pocillos (2) de cultivo que conforman volúmenes de alojamiento de células para el cultivo tridimensional de las mismas; uno o más canales (1) capilares para la circulación de células y/o de medios fluidos, estando dichos canales (1) conectados a los pocillos (2) como medio de perfusión de los mismos; y un puerto de entrada (3) y un puerto de salida (3') para el sembrado de células y/o para la circulación de fluido en dicho canal (1), conectados dichos puertos (3, 3') a los extremos de cada canal (1) capilar. La novedosa configuración de los puertos (3, 3') y de sus canales (1) correspondientes permite mejorar los medios de perfusión microfluídicos conocidos, evitando el uso de elementos complejos para inyectar los medios fluidos, como por ejemplo, bombas de jeringa. Asimismo, la invención permite realizar, de forma simultánea, estudios de cultivo bidimensional y tridimensional. |
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