Parvovirus para el tratamiento de tumores por aplicación intranasal

Un parvovirus para su uso en un método de tratamiento de un tumor y/o metástasis tumoral por administración intranasal, en el que el tumor es un tumor cerebral y/o las metástasis son metástasis cerebrales. Described is the use of an oncolytic parvovirus for the manufacture of a medicament for the treatment of a tumor and/or tumor metastases, in particular a brain tumor, by intranasal administration. A preferred parvovirus is H1-PV. Intranasal parvotherapy can improve the prognosis of said tumors. Parvovirus H1 infection leads to killing of tumor cells but does not harm normal brain cells. Thus, the intranasal use of a parvovirus like H1, a related virus or vectors based on such viruses offers the chance of tumor specific therapy without severe neurological side effects.