Use of polymers based on cross-linked saccharides as bile acid sequestrants (Machine-translation by Google Translate, not legally binding)

Use of polymers based on crosslinked saccharides as bile acid sequestrants. The present invention describes the use of cross-linked saccharide-based polymers as a medicament, particularly for the treatment of diseases that require sequestering sterols and/or bile acids. Such polymers are obtained fr...

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Hauptverfasser: GIRON GONZALEZ, María Dolores, SALTO GONZALEZ, Rafael, SANTOYO GONZALEZ, Francisco, HERNANDEZ MATEO, Fernando, LOPEZ JARAMILLO, Javier
Format: Patent
Sprache:eng ; spa
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Zusammenfassung:Use of polymers based on crosslinked saccharides as bile acid sequestrants. The present invention describes the use of cross-linked saccharide-based polymers as a medicament, particularly for the treatment of diseases that require sequestering sterols and/or bile acids. Such polymers are obtained from either cyclodextrins and/or polysaccharides, such as starch or dextrin, which are cross-linked with bis vinyl sulfones, producing homo- and hetero-polymeric materials. Therefore, said materials can be used in different diseases such as hyperlipidemia, diabetes, atherosclerosis, hypercholesterolemia, hypertriglyceridemia, hyperglycemia and obesity, but it is not limited thereto. (Machine-translation by Google Translate, not legally binding) Uso de polímeros basados en sacáridos entrecruzados como secuestrantes de ácidos biliares. La presente invención describe el uso de polímeros basados en sacáridos entrecruzados como un medicamento, particularmente para el tratamiento de enfermedades que requiere secuestran esteroles y/o ácidos biliares. Tales polímeros se obtienen a partir ya sea de ciclodextrinas y/o polisacáridos, tales como almidón o dextrina, que son entrecruzados con bis vinil-sulfonas, produciendo materiales homo y hetero-poliméricos. Por lo tanto, dichos materiales pueden ser utilizados en diferentes enfermedades tales como la hiperlipidemia, diabetes, arterosclerosis, hipercolesterolemia, hipertrigliceridemia, hiperglucemia y obesidad, pero no se limita a éstas.