Proceso para alquinilar 17-cetoesteroides 16-sustituidos
Un proceso para la preparación de 16-metilen-17α-etinil-17ß-hidroxiesteroides, que comprende (a) tratar un 16-metilen-17-cetoesteroide con un compuesto de fórmula (I)**Fórmula** en la que cada R se selecciona independientemente de alquilo C1-C6 sustituido o no sustituido, arilo sustituido o no susti...
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| creator | GUTIERREZ FUENTES, Luis Gerardo SANDOVAL RODRIGUEZ, Celso Miguel |
| description | Un proceso para la preparación de 16-metilen-17α-etinil-17ß-hidroxiesteroides, que comprende (a) tratar un 16-metilen-17-cetoesteroide con un compuesto de fórmula (I)**Fórmula** en la que cada R se selecciona independientemente de alquilo C1-C6 sustituido o no sustituido, arilo sustituido o no sustituido y halógeno y (b) desililar el 16-metilen-17α-sililetinil-17ß-hidroxiesteroide resultante.
A process ethynylates 16-methylene-17-keto steroids to the corresponding 16-methylene-17α-ethynyl-17 -hydroxy steroids by treatment with silyl-protected lithium acetylides followed by further desilylation. The resulting products are useful intermediates in the preparation of several pharmaceutically active agents, such as e.g. Nestorone® or melengestrol acetate. |
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A process ethynylates 16-methylene-17-keto steroids to the corresponding 16-methylene-17α-ethynyl-17 -hydroxy steroids by treatment with silyl-protected lithium acetylides followed by further desilylation. The resulting products are useful intermediates in the preparation of several pharmaceutically active agents, such as e.g. Nestorone® or melengestrol acetate.</description><language>spa</language><subject>CHEMISTRY ; FOODS OR FOODSTUFFS ; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J ; HUMAN NECESSITIES ; METALLURGY ; ORGANIC CHEMISTRY ; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL ; STEROIDS ; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT ; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160706&DB=EPODOC&CC=ES&NR=2576231T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160706&DB=EPODOC&CC=ES&NR=2576231T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GUTIERREZ FUENTES, Luis Gerardo</creatorcontrib><creatorcontrib>SANDOVAL RODRIGUEZ, Celso Miguel</creatorcontrib><title>Proceso para alquinilar 17-cetoesteroides 16-sustituidos</title><description>Un proceso para la preparación de 16-metilen-17α-etinil-17ß-hidroxiesteroides, que comprende (a) tratar un 16-metilen-17-cetoesteroide con un compuesto de fórmula (I)**Fórmula** en la que cada R se selecciona independientemente de alquilo C1-C6 sustituido o no sustituido, arilo sustituido o no sustituido y halógeno y (b) desililar el 16-metilen-17α-sililetinil-17ß-hidroxiesteroide resultante.
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A process ethynylates 16-methylene-17-keto steroids to the corresponding 16-methylene-17α-ethynyl-17 -hydroxy steroids by treatment with silyl-protected lithium acetylides followed by further desilylation. The resulting products are useful intermediates in the preparation of several pharmaceutically active agents, such as e.g. Nestorone® or melengestrol acetate.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES METALLURGY ORGANIC CHEMISTRY PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL STEROIDS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES |
| title | Proceso para alquinilar 17-cetoesteroides 16-sustituidos |
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