Método de diagnóstico de fibromialgia basado en microRNAs

Method of diagnosing fibromyalgia based on microRNAs. The invention provides a method for the molecular diagnosis of fibromyalgia patients, based on the analysis of the possible alteratión of the levels of specific microRNAs in peripheral blood mononuclear cells. The method comprises the analysis of...

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Bibliographische Detailangaben
Hauptverfasser:	CERDA OLMEDO, Germán, MENA DURAN, Armando Vicente, MONSALVE DOLZ, Vicente Juan, OLTRA GARCIA, Elisa, GARCIA ESCUDERO, María
Format:	Patent
Sprache:	spa
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Method of diagnosing fibromyalgia based on microRNAs. The invention provides a method for the molecular diagnosis of fibromyalgia patients, based on the analysis of the possible alteratión of the levels of specific microRNAs in peripheral blood mononuclear cells. The method comprises the analysis of the levels of the microRNAs miR-223, miR-451, miR-338, miR-143 and miR-145 and the diagnosis of fibromyalgia when at least one, or preferably several thereof have decreased levels with respect to a reference value, which preferably is the level of each microRNA in healthy individuals. Three additional microRNAs are also provided, miR-21, miR-1260b and miR-1908, which can be used as negative controls to confirm the diagnosis. The method facilitates an objective diagnosis of fibromyalgia based on molecular markers that are determined from a sample such as blood, which is easy to obtain and process.