Péptido TGFP-CAP y sus usos
Un péptido TGFP-CAP que tiene una secuencia de aminoácidos derivada del TGF-ß1 (factor -ß1 de crecimiento transformante) y una secuencia de adhesión celular, en donde el péptido TGFP-CAP se representa mediante la siguiente fórmula II: Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-Engarce-secuencia de adhesión a l...
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| creator | KIM, EUN MI SONG, SANG SU CHUNG, YONG JI KIM, JIN SEUK KIM, YOUNG DEUG CHOI, JUN-YOUNG CHO, KYOUNG MI |
| description | Un péptido TGFP-CAP que tiene una secuencia de aminoácidos derivada del TGF-ß1 (factor -ß1 de crecimiento transformante) y una secuencia de adhesión celular, en donde el péptido TGFP-CAP se representa mediante la siguiente fórmula II: Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-Engarce-secuencia de adhesión a la célula (II), en la que la secuencia de adhesión a la célula es RGD (Arg-Gly-Asp) y en la que el engarce comprende 2-10 restos Gly.
The present invention relates to a GFP-CAP peptide having an amino acid sequence derived from TGF- 1 (transforming growth factor- 1) and a cell adhesion sequence, wherein the amino acid sequence derived from TGF- 1 consists of the amino acid sequence of SEQ ID NO:1 and the TGFP-CAP peptide is represented by the following formula I: Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-Cell adhesion sequence (I). The TGFP-CAP peptide of the present invention exhibits excellent anti-angiogenic activity. In addition, the TGFP-CAP peptide of the present invention prevents effectively melanin generation in skin to have skin whitening effects. The present peptide shows much higher stability and permeability to skin than natural-occurring TGF- 1. Such plausible activities and safety of the present peptide enable advantageously to application to drugs, quasi-drugs and cosmetics. |
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The present invention relates to a GFP-CAP peptide having an amino acid sequence derived from TGF- 1 (transforming growth factor- 1) and a cell adhesion sequence, wherein the amino acid sequence derived from TGF- 1 consists of the amino acid sequence of SEQ ID NO:1 and the TGFP-CAP peptide is represented by the following formula I: Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-Cell adhesion sequence (I). The TGFP-CAP peptide of the present invention exhibits excellent anti-angiogenic activity. In addition, the TGFP-CAP peptide of the present invention prevents effectively melanin generation in skin to have skin whitening effects. The present peptide shows much higher stability and permeability to skin than natural-occurring TGF- 1. Such plausible activities and safety of the present peptide enable advantageously to application to drugs, quasi-drugs and cosmetics.</description><language>spa</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20151104&DB=EPODOC&CC=ES&NR=2550145T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20151104&DB=EPODOC&CC=ES&NR=2550145T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KIM, EUN MI</creatorcontrib><creatorcontrib>SONG, SANG SU</creatorcontrib><creatorcontrib>CHUNG, YONG JI</creatorcontrib><creatorcontrib>KIM, JIN SEUK</creatorcontrib><creatorcontrib>KIM, YOUNG DEUG</creatorcontrib><creatorcontrib>CHOI, JUN-YOUNG</creatorcontrib><creatorcontrib>CHO, KYOUNG MI</creatorcontrib><title>Péptido TGFP-CAP y sus usos</title><description>Un péptido TGFP-CAP que tiene una secuencia de aminoácidos derivada del TGF-ß1 (factor -ß1 de crecimiento transformante) y una secuencia de adhesión celular, en donde el péptido TGFP-CAP se representa mediante la siguiente fórmula II: Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-Engarce-secuencia de adhesión a la célula (II), en la que la secuencia de adhesión a la célula es RGD (Arg-Gly-Asp) y en la que el engarce comprende 2-10 restos Gly.
The present invention relates to a GFP-CAP peptide having an amino acid sequence derived from TGF- 1 (transforming growth factor- 1) and a cell adhesion sequence, wherein the amino acid sequence derived from TGF- 1 consists of the amino acid sequence of SEQ ID NO:1 and the TGFP-CAP peptide is represented by the following formula I: Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-Cell adhesion sequence (I). The TGFP-CAP peptide of the present invention exhibits excellent anti-angiogenic activity. In addition, the TGFP-CAP peptide of the present invention prevents effectively melanin generation in skin to have skin whitening effects. The present peptide shows much higher stability and permeability to skin than natural-occurring TGF- 1. Such plausible activities and safety of the present peptide enable advantageously to application to drugs, quasi-drugs and cosmetics.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJAJOLyyoCQzJV8hxN0tQNfZMUChUqG4tFihtDi_mIeBNS0xpziVF0pzMyi6uYY4e-imFuTHpxYXJCan5qWWxLsGG5maGhiamIaEGBsTowYAd74jnQ</recordid><startdate>20151104</startdate><enddate>20151104</enddate><creator>KIM, EUN MI</creator><creator>SONG, SANG SU</creator><creator>CHUNG, YONG JI</creator><creator>KIM, JIN SEUK</creator><creator>KIM, YOUNG DEUG</creator><creator>CHOI, JUN-YOUNG</creator><creator>CHO, KYOUNG MI</creator><scope>EVB</scope></search><sort><creationdate>20151104</creationdate><title>Péptido TGFP-CAP y sus usos</title><author>KIM, EUN MI ; SONG, SANG SU ; CHUNG, YONG JI ; KIM, JIN SEUK ; KIM, YOUNG DEUG ; CHOI, JUN-YOUNG ; CHO, KYOUNG MI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ES2550145TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2015</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>KIM, EUN MI</creatorcontrib><creatorcontrib>SONG, SANG SU</creatorcontrib><creatorcontrib>CHUNG, YONG JI</creatorcontrib><creatorcontrib>KIM, JIN SEUK</creatorcontrib><creatorcontrib>KIM, YOUNG DEUG</creatorcontrib><creatorcontrib>CHOI, JUN-YOUNG</creatorcontrib><creatorcontrib>CHO, KYOUNG MI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KIM, EUN MI</au><au>SONG, SANG SU</au><au>CHUNG, YONG JI</au><au>KIM, JIN SEUK</au><au>KIM, YOUNG DEUG</au><au>CHOI, JUN-YOUNG</au><au>CHO, KYOUNG MI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Péptido TGFP-CAP y sus usos</title><date>2015-11-04</date><risdate>2015</risdate><abstract>Un péptido TGFP-CAP que tiene una secuencia de aminoácidos derivada del TGF-ß1 (factor -ß1 de crecimiento transformante) y una secuencia de adhesión celular, en donde el péptido TGFP-CAP se representa mediante la siguiente fórmula II: Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-Engarce-secuencia de adhesión a la célula (II), en la que la secuencia de adhesión a la célula es RGD (Arg-Gly-Asp) y en la que el engarce comprende 2-10 restos Gly.
The present invention relates to a GFP-CAP peptide having an amino acid sequence derived from TGF- 1 (transforming growth factor- 1) and a cell adhesion sequence, wherein the amino acid sequence derived from TGF- 1 consists of the amino acid sequence of SEQ ID NO:1 and the TGFP-CAP peptide is represented by the following formula I: Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-Cell adhesion sequence (I). The TGFP-CAP peptide of the present invention exhibits excellent anti-angiogenic activity. In addition, the TGFP-CAP peptide of the present invention prevents effectively melanin generation in skin to have skin whitening effects. The present peptide shows much higher stability and permeability to skin than natural-occurring TGF- 1. Such plausible activities and safety of the present peptide enable advantageously to application to drugs, quasi-drugs and cosmetics.</abstract><oa>free_for_read</oa></addata></record> |
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| title | Péptido TGFP-CAP y sus usos |
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