Péptido TGFP-CAP y sus usos

Un péptido TGFP-CAP que tiene una secuencia de aminoácidos derivada del TGF-ß1 (factor -ß1 de crecimiento transformante) y una secuencia de adhesión celular, en donde el péptido TGFP-CAP se representa mediante la siguiente fórmula II: Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-Engarce-secuencia de adhesión a la célula (II), en la que la secuencia de adhesión a la célula es RGD (Arg-Gly-Asp) y en la que el engarce comprende 2-10 restos Gly. The present invention relates to a GFP-CAP peptide having an amino acid sequence derived from TGF- 1 (transforming growth factor- 1) and a cell adhesion sequence, wherein the amino acid sequence derived from TGF- 1 consists of the amino acid sequence of SEQ ID NO:1 and the TGFP-CAP peptide is represented by the following formula I: Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-Cell adhesion sequence (I). The TGFP-CAP peptide of the present invention exhibits excellent anti-angiogenic activity. In addition, the TGFP-CAP peptide of the present invention prevents effectively melanin generation in skin to have skin whitening effects. The present peptide shows much higher stability and permeability to skin than natural-occurring TGF- 1. Such plausible activities and safety of the present peptide enable advantageously to application to drugs, quasi-drugs and cosmetics.