TRIPLE MUTANTE DEL COMPLEJO MYCOBACTERIUM TUBERCULOSIS erp-, phoP- y DIM

The invention relates to a microorganism isolated from the Mycobacterium tuberculosis complex, which comprises the inactivation or deletion of the erp gene, the phoP gene and a gene that prevents the production of phthiocerol dimycocerosates (DIM). Said microorganism can be used for the treatment or...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	GICQUEL, BRIGITTE, AGUILO ANENTO, JUAN IGNACIO, URANGA MAIZ, SANTIAGO, SOLANS BERNAD, LUIS, MARTIN MONTANES, CARLOS
Format:	Patent
Sprache:	spa
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to a microorganism isolated from the Mycobacterium tuberculosis complex, which comprises the inactivation or deletion of the erp gene, the phoP gene and a gene that prevents the production of phthiocerol dimycocerosates (DIM). Said microorganism can be used for the treatment or prevention of tuberculosis, for the treatment of bladder cancer and as a vector or adjuvant. The invention also relates to the pharmaceutical composition comprising said microorganism, to the use thereof as a vaccine, vector or adjuvant, and to the method for producing said microorganism.