Composición farmacéutica para prevenir la disbiosis asociada con la administración enteral de antibióticos

Una composición farmacéutica para prevenir la disbiosis intestinal durante la terapia con antibióticos, destinada para uso oral, que contiene un antibiótico y un prebiótico, caracterizada por que el antibiótico y el prebiótico están incluidos en forma de polvo e incluye, como prebiótico, un oligosacárido seleccionado del grupo que comprende fructooligosacáridos, galactooligosacáridos, xilooligosacáridos, maltooligosacáridos e isomaltooligosacáridos con un grado de polimerización de 2 a 10, con un tamaño de partícula de hasta 0,3 mm y una pureza de al menos un 95 %, y un antibiótico con un tamaño de partícula de 20 a 200 μm, incluyéndose el antibiótico y el oligosacárido en una composición fija a una relación en peso de 1:1 a 1:100, respectivamente. In the first variant, the pharmaceutical composition comprises antibiotic and prebiotic in the form of oligosaccharide of a group comprising fructooligosaccharides, galactooligosaccharides, maltooligosaccharides and isomaltooligosaccharides the polymerisation degree of which ranges form 2 to 20, the particle size is equal to less than 0.3 mm and the purity is of at least 95 %, wherein the antibiotic particle size ranges from 20 to 200 mkm and the antibiotic and oligosaccharide are contained with a mass ratio ranging from 1:1 to 1:100 respectively. In the second variant, the pharmaceutical composition comprises antibiotic which is in the form of a powder with the particle size ranging from 20 to 200 mkm and is selected from a group consisting of beta-lactams, including the combination thereof with bacterial betalactamase inhibitors, azalides, fluoroquinalones, amphenicols, glycopeptides, ansamycins, nitrofurans, phosphonic acid derivatives, cycloserine and trimetoprim. The prebiotic is in the form of a powder oligosaccharide, the polymerisation degree of which ranges from 2 to 10, the particle size is equal to less than 0.3 mm and the purity is of at least 95 %, wherein the antibiotic and oligosaccharide are contained with a mass ratio ranging from 1:1 to 1:100 respectively. The above-mentioned compositions are used for preventing intestinal dysbiosis during antibiotic therapy and are perorally administered. The inventive composition produces a stimulating effect on intestinal lactobacilli and bifidobacteria simultaneously inhibiting the growth and proliferation of extraneous or pathogenic microflora.