Uso del nintedanib para el tratamiento de la fibrosis pulmonar

El compuesto (AK), la (Z)-3-(1-(4-(N-((4-metil-piperazin-1-il)-metilcarbonil)-N-metil-amino)-fenilamino)-1-fenilmetileno]- 6-metoxicarbonil-2-indolinona, o un tautómero, un estereoisómero o una sal fisiológicamente aceptable del mismo, para el uso en el tratamiento de la fibrosis pulmonar. Treatment of immunological (or related) diseases involves administration of an active agent (I) selected from 37 specific (Z)-3-(1-(substituted amino)-1-phenyl-methylene)-2-indolinones and (4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methyl-piperidin-4-yl-methoxy)-quinazoline, optionally together with various other drugs (II). Treatment of immunological diseases or pathological states having an immunological component involves administration of a pharmaceutical composition containing an indolinone or quinazolinone compound (I), optionally together with at least one other drug (II) selected from non-steroidal antiinflammatories, steroids, disease modifying antirheumatic agents, immunosuppressants, biological reaction modifiers and antiinfective agents. (I) is selected from the following compounds and their tautomers, stereoisomers and salts: (1) (Z)-3-(1-(4-piperidin-1-yl-methyl)-phenylamino)-1-phenyl-methylene)-5-(methylsulfonylamino)-2-indolinone; (2) (Z)-3-(1-(4-piperidin-1-yl-methyl)-phenylamino)-1-phenyl-methylene)-5-(ethylsulfonylamino)-2-indolinone; (3) (Z)-3-(1-(4-dimethylaminomethyl)-phenylamino)-1-phenyl-methylene)-5-(ethylsulfonylamino)-2-indolinone; (4) (Z)-3-(1-(4-piperidin-1-yl-methyl)-phenylamino)-1-phenyl-methylene)-5-(phenylsulfonylamino)-2-indolinone; (5) (Z)-3-(1-(4-piperidin-1-yl-methyl)-phenylamino)-1-phenyl-methylene)-5-(4-amino-phenylsulfonylamino)-2-indolinone; (6) (Z)-3-(1-(4-pyrrolidin-1-yl-methyl)-phenylamino)-1-phenyl-methylene)-5-(ethylsulfonylamino)-2-indolinone; (7) (Z)-3-(1-(4-(3-aminopropyl)-piperidin-1-yl-methyl)-phenylamino)-1-phenyl-methylene)-5-(ethylsulfonylamino)-2-indolinone; (8) (Z)-3-(1-(4-(N-(piperidin-1-yl-methylcarbonyl)-N-methylamino)-phenylamino)-1-phenyl-methylene)-5-(phenylsulfonylamino)-2-indolinone; (9) (Z)-3-(1-(4-(N-(2-dimethylamino-ethyl)-N-methylsulfonyl-amino)-phenylamino)-1-phenyl-methylene)-5-(N-methyl-N-phenylsulfonylamino)-2-indolinone; (10) (Z)-3-(1-(4-(N-methyl-N-(piperidin-1-yl-methylcarbonyl)-amino)-phenylamino)-1-phenyl-methylene)-5-(N-methyl-N-phenylsulfonylamino)-2-indolinone; (11) (Z)-3-(1-(2-benzimidazolyl-amino)-1-phenyl-methylene)-5-amido-2-indolinone; (12) (Z)-3-(1-(4-N-methyl-propionylamino)-phenylami