Moléculas de unión para las proteínas similares al factor VIII y factor VIII humano

polipéptido que se une a un Factor VIII o un fragmento de este que retiene actividad procoagulante del factor VIII, en donde dicho polipéptido comprende una secuencia de aminoácido seleccionada del grupo que consiste de: Phe-Gly-Cys-Ser-Trp-Leu-Phe-Pro-Cys-Pro-Phe (sec. con núm. de ident.:5); Pro-Hi...

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Hauptverfasser:	YU, JINAN, DEETZ, JEFFREY S, KELLEY, BRIAN D, BOOTH, JAMES E, POTTER, DANIEL M
Format:	Patent
Sprache:	spa
Schlagworte:	BEER BIOCHEMISTRY BLASTING CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HEATING INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIGHTING MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MECHANICAL ENGINEERING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PHYSICS POSITIVE DISPLACEMENT MACHINES FOR LIQUIDS PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS PUMPS PUMPS FOR LIQUIDS OR ELASTIC FLUIDS SPIRITS TESTING THEIR RELEVANT APPARATUS TRANSPORTING VINEGAR WEAPONS WINE
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Beschreibung
Zusammenfassung:	polipéptido que se une a un Factor VIII o un fragmento de este que retiene actividad procoagulante del factor VIII, en donde dicho polipéptido comprende una secuencia de aminoácido seleccionada del grupo que consiste de: Phe-Gly-Cys-Ser-Trp-Leu-Phe-Pro-Cys-Pro-Phe (sec. con núm. de ident.:5); Pro-His-Cys-Asn-Trp-Leu-Phe-Pro-Cys-Ser-Leu (sec. con núm. de ident.:6); Arg-Leu-Cys-Ser-Trp-Ile-Ser-Pro-Cys-Ser-Ala (sec. con núm. de ident.:7); Phe-His-Cys-Ile-Gly-Val-Trp-Phe-Cys-Leu-His (sec. con núm. de ident.:8); y Arg-Leu-Cys-Ser-Trp-Val-Ser-Pro-Cys-Ser-Ala (sec. con núm. de ident.:9). Methods for detecting human factor VIII or factor VIII-like polypeptides in and isolating it from solutions such as blood or conditioned media are disclosed, together with reagents suitable for the purpose comprising binding moieties that recognize human factor VIII and/or a factor VIII-like polypeptide and form a binding complex therewith. Preferred polypeptide binding moieties are particularly disclosed.