COMPOUNDS USED FOR THE TREATMENT OF BACTERIAL INFECTIONS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPOUNDS, METHOD FOR IDENTIFYING SAME AND USES THEREOF

The invention relates to a series of compounds used to reduce or eliminate processes determining bacterial virulence and pathogenicity and bacterial adhesion to inert surfaces or cells, such as the production of adhesins, flagellar motility and the formation of bacterial biofilms and exopolysacchari...

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Bibliographische Detailangaben
Hauptverfasser: MONTERO MACARRO, MANUEL, MUNOZ PEREZ, FRANCISCO JOSE, BAROJA FERNANDEZ, EDURNE, ALMAGRO ZABALZA, GOIZEDER, RAHIMPOUR, MEHDI, POZUETA ROMERO, JAVIER
Format: Patent
Sprache:eng ; spa
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Zusammenfassung:The invention relates to a series of compounds used to reduce or eliminate processes determining bacterial virulence and pathogenicity and bacterial adhesion to inert surfaces or cells, such as the production of adhesins, flagellar motility and the formation of bacterial biofilms and exopolysaccharides. Said compounds can be used for the production of antibacterial pharmaceutical compositions or antiseptic compositions for the treatment of a wide range of bacterial infections, such as, for example, E. coli, S. typhi, S. dysenteriae, V. cholerae, P. aeruginosa, H. pylori, L. monocytogenes, C. difficile and S. pyogenes. The invention also relates to a series of compounds that promote the bond between beneficial rhizobacteria and cells of plant roots. Furthermore, the invention relates to a method for the identification of said compounds. La presente invención describe una serie de compuestos útiles para reducir o anular procesos determinantes de la patogenicidad y virulencia bacterianas y de la adherencia bacteriana a superficies inertes o células tales como la producción de adhesinas, la motilidad flagelar y la formación de EPSs y biofilms bacterianos. Estos compuestos pueden usarse para la elaboración de composiciones farmacéuticas antibacterianas o de composiciones antisépticas para el tratamiento de un amplio abanico de infecciones bacterianas, como por ejemplo, E. coli, S. typhi, S. dysenteteriae, V. chlolerae, P. aeruginosa, H. pylori, L. monocytogenes, C. difficile y S. pyogenes. Además, se describe un procedimiento para la identificación de dichos compuestos.