Sales de tiotropio, procedimiento para su preparación y formulaciones de medicamentos que las contienen

Cloruro de tiotropio cristalino, el cual se caracteriza porque en el diagrama de rayos X en polvo presenta, entre otros, los valores característicos d >= 6,15 Å; 5,58 Å; 4,45 Å y 3,93 Å. Preparation of new tiotropilium salts (1) by subjecting a different tiotropilium salt (2) to anion exchange wi...

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Hauptverfasser:	BANHOLZER, ROLF, SIEGER, PETER, PFRENGLE, WALDEMAR
Format:	Patent
Sprache:	spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	Cloruro de tiotropio cristalino, el cual se caracteriza porque en el diagrama de rayos X en polvo presenta, entre otros, los valores característicos d >= 6,15 Å; 5,58 Å; 4,45 Å y 3,93 Å. Preparation of new tiotropilium salts (1) by subjecting a different tiotropilium salt (2) to anion exchange with an ion source in a solvent. Preparation of new tiotropilium salts of formula (1) by subjecting a different tiotropilium salt of formula (2) to anion exchange with an ion source (Kat-X) in a solvent. [Image] X : anion; Y : anion, different from X, i.e. halo, 1-10C alkyl-sulfonate or -sulfate, or 6-10C arylsulfonate; Kat : cation. An independent claim is also included for new compounds (1) and (2), except where Y/X = bromo, optionally as solvates or hydrates. ACTIVITY : Antiasthmatic. No details of tests for antiasthmatic activity are given. MECHANISM OF ACTION : Anticholinergic.