COLY-MYCIN DERIVATIVES

The present invention relates to the isolation, cloning and sequencing of the group of genes involved in the biosynthesis of coly-mycin by Streptomyces spp. CS40, and to the use of said genes to increase the production of coly-mycin and/or associated analogous compounds or derivatives by means of pr...

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Hauptverfasser:	SIALER GUERRERO, CARLOS ALBERTO, GONZALEZ SABIN, JAVIER, GARCIA LLORENTE, IGNACIO, SALAS FERNANDEZ, JOSE ANTONIO, MENDEZ FERNANDEZ, CARMEN, MIGUEL VIOR, NATALIA, MORIS VARAS, FRANCISCO, FERNANDEZ BRANA, ALFREDO
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to the isolation, cloning and sequencing of the group of genes involved in the biosynthesis of coly-mycin by Streptomyces spp. CS40, and to the use of said genes to increase the production of coly-mycin and/or associated analogous compounds or derivatives by means of productive strains. Said compounds produced in the present invention can be used to treat several diseases, such as cancer, neuro-degenerative diseases and infectious diseases. Derivados de colismicina. La presente invención describe el aislamiento, clonación y secuenciación de la agrupación de genes implicados en la biosíntesis de colismicina por Streptomyces spp. CS40, y el uso de dichos genes para incrementar la producción de colismicina y/o compuestos análogos o derivados relacionados por medio de cepas productoras. Dichos compuestos producidos en la presente invención son aplicables en el tratamiento de diversas enfermedades como, por ejemplo, el cáncer, enfermedades neurodegenerativas y enfermedades infecciosas.