DESARROLLO Y USO DE NANOPARTICULAS LIPIDICAS CONTENIENDO EDELFOSINA Y OTROS ETERES DE FOSFOLIPIDOS EN LA TERAPIA ANTITUMORAL Y ANTIPARASITARIA

Development and use of lipid nanoparticles containing edelfosine and other phospholipid ethers in antitumor and antiparasitic therapy. The present invention provides compositions comprising nanoparticles of lipid origin containing an ether of phospholipids. The invention also relates to the use of these compositions for the preparation of medicaments for the oral treatment of cancer and of leishmaniasis. The pharmaceutical compositions of the present invention entail a remarkable increase in oral bioavailability, and an improvement in the treatment against the use of a free phospholipid ether, including inhibition of metastasis, which implies a lower treatment dose of the antitumor agent. (Machine-translation by Google Translate, not legally binding)