BIOTRANSFORMACION DE COMPUESTOS BIOLOGICAMENTE ACTIVOS A PARTIR DE SUBSTANCIAS QUIMICAS DE DIFERENTES CLASES POR MEDIO DE LA ENZIMA LACCASA Y PEROXIDASA DE MANGANESO

Procedimiento de fabricación de sustancias biológicamente activas a partir de medicamentos, caracterizado por el hecho de que los medicamentos son antibióticos β-lactámicos y por que por el efecto de la enzima que forma radicales laccasa EC 1.10.3.2. (clasificación según la Nomenclatura internaciona...

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Hauptverfasser:	SCHAUER, FRIEDER, HAMMER, ELKE, SCHAFER, ANNETT, JULICH, WOLF DIETER, LINDEQUIST, ULRIKE, JONAS, ULRIKE
Format:	Patent
Sprache:	spa
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE FISHING FORESTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TRAPPING VINEGAR WINE
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Zusammenfassung:	Procedimiento de fabricación de sustancias biológicamente activas a partir de medicamentos, caracterizado por el hecho de que los medicamentos son antibióticos β-lactámicos y por que por el efecto de la enzima que forma radicales laccasa EC 1.10.3.2. (clasificación según la Nomenclatura internacional de enzimas (Enzym Nomenclature, Academic Press, Inc, 1992, pags. 24-154)) se pueden obtener productos de acoplamiento con enlaces heteromoleculares conteniendo moléculas aromáticas como compuestos con un espectro de actividad modificada que presentan un comportamiento de repartición modificado con la medida de que la molécula aromática que está sustituida es el benceno. A process for the preparation of biologically active compounds, wherein active substances having additional functional groups and a modified spectrum of activity and modified application properties are obtainable from medicinal substances and plant protective agents as substrates which bear at least one amino or hydroxy functional group by using a one-electron reaction catalyzed by enzymes or compositions having enzymatic activity and a broad spectrum of substrates, characterized in that free-radical forming enzymes are employed as enzymes and/or supernatants of ligninolytic fungi in solution are employed as compositions having enzymatic activity, wherein the following can be introduced as additional functional groups: A) polyfunctional synthones which provide the active substance with an altered dissolving behavior in aqueous and lipophilic systems and a high interfacial activity; B) aromatic molecules, heteroaromatic compounds; C) heterocyclic compounds; D) active substances having an independent biological activity; E) active substances combining an independent activity and surfactant properties in one molecule; which yield coupling products being covalently linked with the starting materials and having an altered partition behavior which enable polyfunctional interactions with the target organism.