USE OF DERIVATES OF 6-SUBSTITUTED 3-PHENYLCOUMARINS AND PREPARATION OF NEW DERIVATES

The present invention is directed at the use of compounds of formula I, being derivatives of 3-phenylcoumarins substituted in position 6, for the preparation of medicaments for treating disorders deriving from hyperactivity of the MAO-B isoform, such as degenerative disorders of the central nervous...

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Hauptverfasser: CORREIRA PINTO CARVALHO DE MATOS MARIA JOAO, SANTANA PENIN LOURDES, VINA CASTELAO DOLORES, ORALLO CAMBEIRO FRANCISCO, QUEZADA GONZALEZ ELIAS NEFTALI, YANEZ JATO MATILDE
Format: Patent
Sprache:eng ; spa
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Zusammenfassung:The present invention is directed at the use of compounds of formula I, being derivatives of 3-phenylcoumarins substituted in position 6, for the preparation of medicaments for treating disorders deriving from hyperactivity of the MAO-B isoform, such as degenerative disorders of the central nervous system or obesity. Furthermore it is directed at the preparation of certain compounds of formula I which present high activity and the use thereof. La presente invención se dirige al uso de compuestos de fórmula I, que son derivados de 3-fenilcumarinas con, sustitución en la posición 6, para la preparación de medicamentos para tratar trastornos derivados de la hiperactividad, de la isoforma de la MAO-B, como trastornos degenerativos del sistema nervioso central o la obesidad. También se dirige, a la preparación de ciertos compuestos de fórmula I que presentan elevada actividad y su uso.