PROTEINA MORFOGENETICA DE HUESO-2 (BMP-2) CON UN DOMINIO DE UNION ESPECIFICO A COLAGENO TIPO I, PROCEDIMIENTO DE OBTENCION Y APLICACIONES

Morphogenetic protein of bone-2 (bmp-2) with a specific binding domain to type i collagen, obtaining procedure and applications. The present invention comprises the production and application of a fusion protein consisting of a rhbmp-2 modified to specifically bind to collagen with a collagen binding domain derived from von willebrand factor. The resulting fusion protein (rhbmp-2-cbd) has a higher affinity for collagen, this unión being very stable over time, and retaining the osteoinductive activity, being able to induce the formation of new bone even at concentrations below the known for native rhbmp-2. Furthermore, in combination with a collagenic carrier free of any other growth factor, such as an absorbable collagen sponge, low concentrations of rhbmp-2-cbd are able to induce the formation of new bone when implanted in vivo. (Machine-translation by Google Translate, not legally binding)